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NABP Exam NAPLEX Topic 5 Question 97 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 97
Topic #: 5

[All NAPLEX Questions]

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

ACYP3A4

BCYP2C9

CCYP2C19

DCYP2D9

ECYP1A2

Show Suggested Answer

Suggested Answer: C

Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).

by Shelton at Nov 18, 2024, 03:59 AM

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Kelvin

3 months ago

I'm going with B) CYP2C9. Omeprazole inhibiting that enzyme is like a superhero teaming up with a supervillain to take down warfarin. Classic interaction!

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Marget

3 months ago

Yeah, it's like a superhero-villain duo! Omeprazole and warfarin teaming up for some unexpected effects.

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Trina

3 months ago

B) CYP2C9 is correct. Omeprazole inhibits this enzyme, leading to increased INR and PT when used concomitantly with warfarin.

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Lashaun

3 months ago

Haha, you guys are overthinking this. It's obviously B) CYP2C9. Warfarin and omeprazole, a perfect combo for a trip to the hospital!

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Dominga

3 months ago

D) CYP2D9 is not the enzyme involved in the interaction between warfarin and omeprazole.

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Sabra

3 months ago

C) CYP2C19 is not the enzyme affected by omeprazole in this case.

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Margery

3 months ago

B) CYP2C9 is the correct answer. It's important to be cautious with warfarin and omeprazole.

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Maryann

3 months ago

A) CYP3A4 is the enzyme that omeprazole inhibits.

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Val

4 months ago

But omeprazole inhibits CYP2C19, which is involved in warfarin metabolism.

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Pearlene

4 months ago

C'mon, it's gotta be C) CYP2C19. Everyone knows that's the one responsible for warfarin metabolism, and omeprazole messes with that.

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Belen

3 months ago

Okay, thanks for clarifying. I'll go with C) CYP2C19 then.

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Nan

3 months ago

No, I'm pretty sure it's C) CYP2C19. That's the main one affected by omeprazole.

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Royal

3 months ago

But what about A) CYP3A4? Could that also be involved?

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Yvette

3 months ago

I think you're right, it's C) CYP2C19.

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Donette

4 months ago

I disagree, I believe the correct answer is B) CYP2C9.

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Val

4 months ago

I think the answer is C) CYP2C19.

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Angelyn

4 months ago

Hmm, I think the answer is B) CYP2C9. Omeprazole is known to inhibit this enzyme, which is also involved in the metabolism of warfarin.

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Antonio

3 months ago

Yes, regular monitoring and dose adjustments may be necessary to prevent bleeding risks.

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Dick

4 months ago

It's important to monitor patients closely when using both medications together.

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Solange

4 months ago

That's correct, the interaction can lead to increased INR and PT.

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Valda

4 months ago

I agree, omeprazole inhibits CYP2C9 which is involved in warfarin metabolism.

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