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NABP Exam NAPLEX Topic 5 Question 97 Discussion

Actual exam question for NABP's NAPLEX exam
Question #: 97
Topic #: 5
[All NAPLEX Questions]

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

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Suggested Answer: C

Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).


by Shelton at Nov 18, 2024, 03:59 AM

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Val
18 hours ago
I think the answer is C) CYP2C19.
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Angelyn
19 hours ago
Hmm, I think the answer is B) CYP2C9. Omeprazole is known to inhibit this enzyme, which is also involved in the metabolism of warfarin.
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