NABP Exam NAPLEX Topic 3 Question 89 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 89
Topic #: 3

JT is a 58-year-old women who is on vancomycin empirically for pyomyositis confirmed by MRI. Surgical debridement has successfully removed infected tissue and pus. C&S of the infected tissue comes back MSSA sensitive to everything on the panel. JT is allergic to PCN (rash), she has had cephalosporin for her UTI in the past with no problem.

What would be the most appropriate antibiotics to switch to while JT is still in the hospital?

AOxacillin

BDoxycycline

CCeftaroline

DDaptomycin

ECefazolin

Show Suggested Answer

Suggested Answer: E

Cefazolin or an antistaphylococcal penicillin (oxacillin or nafcillin) is recommended for this patient because the C&S results indicate MSSA. Since the patient develops a rash to penicillins, it would be acceptable to use cefazolin in this case.

https://academic.oup.com/cid/article/59/2/e10/2895845/Practice-Guidelines-for-the-Diagnosis-and

by Winifred at Aug 22, 2024, 07:47 PM

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Shawna

6 months ago

I'm gonna go with Cefazolin. It's the most cost-effective option, and let's be honest, who doesn't love a good cephalosporin?

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Alayna

6 months ago

Ceftaroline? Really? That's overkill for a simple MSSA infection. Cefazolin is the way to go, hands down.

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Frederick

5 months ago

Ceftaroline might be too strong for this case, Cefazolin seems like the safer choice.

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Vivan

5 months ago

I think Daptomycin could also be a good option for JT.

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Shawnta

5 months ago

I agree, Cefazolin is a good choice for MSSA infection.

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Mitsue

6 months ago

Oxacillin is the obvious choice. It's the standard treatment for MSSA infections, and with no cephalosporin issues, it's a perfect fit.

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Jutta

6 months ago

Daptomycin seems like a good choice here. It's effective against MSSA and doesn't have any cross-reactivity with PCN allergies.

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Cherrie

5 months ago

Oxacillin could be a good choice as well, it's effective against MSSA and has been used for similar infections.

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Alpha

5 months ago

I think Cefazolin might be a better option since it's also effective against MSSA and has a lower risk of resistance.

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Vicki

5 months ago

Ceftaroline could also be a good choice since JT has tolerated cephalosporin in the past.

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Huey

6 months ago

I agree, Daptomycin would be a good option for JT in this case.

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Charisse

6 months ago

I think the most appropriate antibiotic to switch to is Cefazolin. It's the safest option since JT has no issues with cephalosporins.

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Laurel

6 months ago

Ceftaroline could also be a good option since it covers MRSA and MSSA.

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Carlton

6 months ago

I agree, Cefazolin would be a good choice since JT has tolerated cephalosporins before.

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Gladys

7 months ago

I would go with Cefazolin instead, it's also effective against MSSA and has a good safety profile.

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Bettina

7 months ago

I agree, Ceftaroline would be a good choice since it covers MSSA and JT has had cephalosporin before.

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Earnestine

7 months ago

I think the most appropriate antibiotic to switch to would be Ceftaroline.

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