NABP NAPLEX Exam - Topic 10 Question 81 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 81
Topic #: 10

[All NAPLEX Questions]

Which of the following is true regarding extent of absorption of drugs?

AAfter oral ingestion of drugs, the absorption of drug may be incomplete

BDrugs which are too lipophilic cannot cross the lipid cell membrane

CDrugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

DP-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

EGrape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

Show Suggested Answer

Suggested Answer: A

The dihydropyridine drug -- nifedipine -- is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.

by Yoko at May 09, 2024, 07:01 AM

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Celia

4 months ago

B is misleading, lipophilic drugs can cross membranes, just slower.

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Brittni

4 months ago

Wait, grape juice affects drug absorption? That's surprising!

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Elbert

4 months ago

C makes sense, hydrophilic drugs struggle with that water layer.

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Paola

5 months ago

I disagree with D, P-glycoprotein actually reduces absorption.

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Tracey

5 months ago

A is definitely true, absorption can be incomplete.

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Kenneth

5 months ago

I vaguely remember something about P-glycoprotein, but I thought it was more about limiting absorption rather than enhancing it. So, I’m unsure about option D.

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Verdell

5 months ago

I practiced a question similar to this, and I recall that hydrophilic drugs struggle with crossing membranes due to their solubility issues. So, option C seems plausible.

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Alfred

5 months ago

I'm not entirely sure, but I think lipophilic drugs can actually cross cell membranes. Isn't that why they are often more bioavailable?

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Natalie

6 months ago

I remember that oral drug absorption can be incomplete, especially with certain formulations. So, I think option A might be true.

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Stephen

6 months ago

Alright, let me review what I know about lipophilicity, hydrophilicity, and transporters like P-glycoprotein. I think I can narrow this down.

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Tomoko

6 months ago

Okay, I know the basics of drug absorption, so I should be able to figure this out.

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Cassi

6 months ago

Hmm, I'm a bit unsure about the details of drug absorption. Let me think this through carefully.

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Scarlet

6 months ago

This question seems straightforward, I think I can handle it.

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Emily

6 months ago

Ugh, I'm not too confident in my pharmacology knowledge. This is going to be tricky.

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Denny

6 months ago

The Form-Based Composer seems like it could work, but I'm not confident that it would provide the level of control and customization needed for this type of test.

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Alesia

6 months ago

I think the answer is True, but I'm a bit uncertain. I'll make a note to research this topic more before the exam to solidify my understanding.

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Nan

6 months ago

Okay, let me think this through. The question is asking about the first program the Linux kernel starts at boot time using System V init. That means it's likely going to be one of the standard init-related paths, not something more obscure. I'm going to go with /sbin/init as my best guess.

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Adell

11 months ago

Option E is just plain funny. Grape juice as a drug absorption inhibitor? Maybe they should add wine as a choice too, for a more 'spirited' exam experience.

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Whitley

10 months ago

C) Drugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

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Keneth

10 months ago

B) Drugs which are too lipophilic cannot cross the lipid cell membrane

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Brandon

10 months ago

A) After oral ingestion of drugs, the absorption of drug may be incomplete

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Haydee

11 months ago

D is incorrect. P-glycoprotein is an efflux transporter that actually reduces drug absorption, not enhances it. Grape juice inhibiting P-glycoprotein could potentially increase drug absorption, not decrease it.

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William

11 months ago

I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.

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Willie

9 months ago

User 4: D) P-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

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Ciara

10 months ago

User 3: I'm not sure about B and C. Shouldn't the drug's physicochemical properties be balanced to achieve optimal absorption? Maybe I need to review my lipophilicity and hydrophilicity concepts.

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Dortha

10 months ago

User 2: E) Grape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

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Royce

11 months ago

User 1: A) After oral ingestion of drugs, the absorption of drug may be incomplete

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Lourdes

12 months ago

I agree with A. Incomplete absorption is a common phenomenon, and it's crucial to understand the factors affecting it, like you mentioned.

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Kent

11 months ago

User 2: Yeah, it's important to consider factors affecting absorption.

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Asuncion

11 months ago

User 1: I think A is true, incomplete absorption happens often.

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Zoila

12 months ago

Option A is correct. Drug absorption can indeed be incomplete after oral administration due to various factors like first-pass metabolism, drug efflux transporters, and physicochemical properties of the drug.

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