NABP Exam NAPLEX Topic 10 Question 81 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 81
Topic #: 10

[All NAPLEX Questions]

Which of the following is true regarding extent of absorption of drugs?

AAfter oral ingestion of drugs, the absorption of drug may be incomplete

BDrugs which are too lipophilic cannot cross the lipid cell membrane

CDrugs which are too hydrophilic are not soluble enough to cross the water layer adjacent to the cell

DP-glycoprotein is an efflux transporter which is present in the enterocytes and it enhances the absorption of drug

EGrape juice activates P-glycoprotein leading to substantial inhibition of absorption of drugs

Show Suggested Answer

Suggested Answer: A

The dihydropyridine drug -- nifedipine -- is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.

by Yoko at May 09, 2024, 07:01 AM

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Murray

1 days ago

That's a good point, but I still think A is more likely based on what I've studied.

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Gail

5 days ago

I disagree, I believe B is true because lipophilic drugs have difficulty crossing cell membranes.

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Murray

10 days ago

I think A is true because some drugs are not fully absorbed after oral ingestion.

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