NABP Exam NAPLEX Topic 10 Question 18 Discussion

Actual exam question for NABP's NAPLEX exam

Question #: 18
Topic #: 10

Concomitant use of warfarin and omeprazole is associated with increased INR and prothrombin time(PT). What enzyme dose the omeprazole inhibits that is metabolized by warfarin?

ACYP3A4

BCYP2C9

CCYP2C19

DCYP2D9

ECYP1A2

Show Suggested Answer

Suggested Answer: C

Omeprazole is CYP2C19 inhibitor which can prolong the elimination of warfarin, particularly R-warfarin. R- warfarin is partially metabolized by CYP2C19. The combined use of omeprazole and warfarin has been associated with reports of increased INR and prothrombin time (PT).

by Keneth at May 05, 2022, 01:49 PM

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